Investigating Predictors of Retreatment following Initial Antivascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis.

ABSTRACT:

Purpose

To investigate factors contributing to retreatment after antivascular endothelial growth factor (anti-VEGF) therapy in patients with retinopathy of prematurity (ROP).

Methods

All relevant publications released up to November 2022 from PubMed, Google Scholar, and Scopus were evaluated. An Excel checklist was developed for data extraction, including author names, publication year, sample size, mean gestational age (GA), birth weight (BW), zone of ROP, total and zone-specific retreatment incidence, and the percentage of aggressive posterior ROP eyes. The primary outcome was the incidence of retreatment (IR). The mixed methods appraisal tool was used to assess the quality of the papers.

Results

The total IR was 19% (95% confidence interval (CI): 15%-23%). Among ch

SUBMITTER: Chaibakhsh S 

PROVIDER: S-EPMC12668653 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature