Prognostic Factors in Pleural Mesothelioma Patients Receiving First-Line Chemotherapy: Establishing the PLECH Baseline Risk Score.

ABSTRACT:

Introduction

Pleural mesothelioma (PM) is a rare and aggressive cancer where prognostic assessment is crucial. Traditional prognostic scores such as the European Organization for Research and Treatment of Cancer (EORTC) and the Cancer and Leukemia Group B (CALGB) have limitations, particularly in reflecting contemporary treatments and demographic diversities, while more recent scores often include novel biomarkers, not widely available and validated. Our goal was to create an effective prognostic score for PM using readily available baseline data.

Methods

A retrospective cohort study at two Mexican cancer centers included patients with unresectable PM treated with the first-line chemotherapy from 2010 to 2023. Baseline variables' associations with overall survival (OS) and p

SUBMITTER: Guijosa A 

PROVIDER: S-EPMC12668723 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature