Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps.

ABSTRACT: Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk-safety assessment. Out of 4102 search outputs, only 62 studies on BF disposition and biological effects met screening and eligibility criteria. Our findings demonstrate oral, dermal, and inhalation toxicity of BF. Studies suggest potential effects, including immunotoxic, endocrine, and reproductive effects, but lack multi-level substantiation and modeling approaches amidst risk biases. Emerging evidence of anxiogenic, depression-like, and Parkinsonian-like effects, which implicate monoaminergic, metabolic, and enzymatic

SUBMITTER: Moreira CVL 

PROVIDER: S-EPMC12668871 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature