High Airway-To-Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in COPD.

ABSTRACT:

Background and objective

The effects of the volume mismatch between the airway and lung vasculature on exacerbation in chronic obstructive pulmonary disease (COPD) is uncertain. We aimed to examine the association between an increased volume ratio of the airway to lung blood vessels (AVR) and exacerbations, regardless of visually assessed bronchiectasis (modified Reiff [mReiff] score) and extrapulmonary vasculature on computed tomography (CT), in patients with COPD during a 5-year follow-up period.

Methods

Participants were recruited from the Hokkaido COPD Cohort Study (original, N = 96) and Kyoto University cohort (validation, N = 130). CT-derived indices of the airway and vasculature, mReiff scores, and ratio of pulmonary artery diameter to aorta diameter (PA/Ao) were eval

SUBMITTER: Wakazono N 

PROVIDER: S-EPMC12668884 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature