Risk of Stroke in Patients With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Cohort Study of 183,504 Subjects.

ABSTRACT:

Background

Major psychiatric disorder, including schizophrenia, bipolar disorder, and major depressive disorder, has been individually associated with increased risk of stroke. However, few studies have directly compared the stroke risk across these diagnostic groups within a unified cohort framework while accounting for stroke subtypes and relevant confounders.

Methods

Using Taiwan's National Health Insurance Research Database, we identified 30,945 patients with schizophrenia, 30,360 with bipolar disorder, 30,447 with major depressive disorder, and 91,752 age-matched controls without psychiatric illness between 2001 and 2009. Participants were followed until death or the end of 2011. Cox regression models were used to estimate the hazard ratio (HR) for ischemic and hemorrha

SUBMITTER: Huang MH 

PROVIDER: S-EPMC12668889 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature