<i>Puerariae lobatae</i> Radix aqueous extract ameliorates asymptomatic hyperuricemia in a potassium oxonate-induced rat model by dual modulation of uric acid production and excretion.

ABSTRACT:

Background

Puerariae lobatae Radix (PLR) is a well-known traditional Chinese medicine and edible natural nutrient, with diverse biological activities, including anti-diabetes, anti-inflammatory, anti-oxidant and liver protection. However, the effects and underlying mechanisms of PLR in hyperuricemia (HUA) are unclear.

Methods

The present study focused on the regulatory effects of aqueous extract from PLR on the asymptomatic hyperuricemia rat model, induced by potassium oxonate. Serum uric acid (SUA), serum blood urea nitrogen (BUN), creatinine (CRE), serum inflammatory factors, anthine oxidase activity, hepatic and renal tissue morphology were measured to assess the anti-hyperuricemia effect. After which, 16SrDNA sequencing and the UHPLC-Q-Orbitrap-MS/MS with network

SUBMITTER: Zhao D 

PROVIDER: S-EPMC12668913 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature