Radon exposure delays the development of skin lesions in a mouse model of psoriasis.

ABSTRACT:

Introduction

The chronic inflammatory skin disease psoriasis vulgaris is characterized by itchy plaques, often accompanied by life-threatening comorbidities severely impairing the quality of life and cause high socioeconomic costs. Despite the known cancer risk, radon inhalation is used as a treatment for various chronic inflammatory diseases, including psoriasis. Knowledge about the underlying mechanism is scarce, largely due to the lack of suitable mouse models.

Methods

Here, we used transgenic mice that spontaneously develop chronic psoriatic skin lesions inflicted by constitutive low-level IL-17A-production by CD11c⁺ cells (CD11c-IL-17A^ind/ind mice). Mice underwent single or multiple radon exposures under therapy relevant conditions and observed unt

SUBMITTER: Lerchl S 

PROVIDER: S-EPMC12669134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature