Between similarity and difference: network dynamics of the hippocampal- parahippocampal circuitry in pattern separation of male Wistar rats.

ABSTRACT:

Introduction

Studies indicate that pattern separation for spatial and object information involves structures of the temporal cortex (lateral entorhinal and perirhinal cortices) and hippocampus (dentate gyrus and CA3), which are particularly sensitive to aging. However, little is known about how the hippocampal network, the anteroposterior axis of these regions, and the excitatory-inhibitory circuit contribute to the recognition and separation of object patterns.

Methods

This study investigated the expression of c-Fos and PV along the anteroposterior axis of the hippocampus in a multi-trial task to assess the recognition of novel objects and recognition of novel objects with different levels of similarity. Five groups of animals performed tasks with different similarity deman

SUBMITTER: Araujo APC 

PROVIDER: S-EPMC12669181 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature