Multidirectional wall shear stress is associated with thrombotic risk in isolated coronary artery ectasia.

ABSTRACT:

Background

Thrombosis is a critical and lethal complication of isolated coronary artery ectasia (iCAE), potentially linked to hemodynamic changes, particularly wall shear stress (WSS) alterations. However, the association between thrombosis and multidirectionality of blood flow, and thus of WSS, is not well defined.

Methods

This study retrospectively enrolled 34 patients diagnosed with iCAE. In total, 53 ectatic coronary arteries were identified for hemodynamics analysis, of which 11 had thrombosis and 42 did not. We used an automated workstation for coronary three-dimensional reconstruction and conducted computational fluid dynamics (CFD) analysis. Particularly, we analyzed the mean changes in the following multidirectional WSS metrics at the ectatic segments: time-averaged

SUBMITTER: Sun J 

PROVIDER: S-EPMC12669196 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature