Global burden of lower respiratory infections attributable to cytomegalovirus, 1990-2021: a systematic analysis from the MICROBE database.

ABSTRACT:

Objectives

This study aimed to investigate the global epidemiological characteristics and disease burden of lower respiratory infections (LRIs) attributable to cytomegalovirus (CMV) from 1990 to 2021.

Methods

We systematically assessed the global burden and temporal trends of CMV-associated LRIs across different ages, sexes, geographic regions, and socioeconomic statuses using data from the MICROBE database spanning 1990-2021. Key metrics included mortality, disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASRs).

Results

Globally, the number of DALYs due to CMV-attributed LRI decreased from an estimated 734,208 (95% UI: 612,175-856,241) in 1990 to 530,465 (95% UI: 469,046-591,884) in 2021, while the number of deaths increased fro

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12669215 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature