Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks.

ABSTRACT:

Background

Assessing aging pace through biological age offers a precise perspective and underscores the need for further investigation into organ-level disparities.

Methods

This observational study utilized multi-scale phenotypes from the Taizhou Imaging Study, encompassing brain imaging, cognitive assessment, blood biochemistry, omics, and physical measures. A total of 904 individuals (403 men and 501 women) aged 55-65 years were included. Age correlations with single and composite phenotypes were assessed, and multi-modal aging clocks were developed, incorporating organ systems, cognition, and the whole body.

Results

Here we show that composite phenotypes, such as those of cardiovascular system and bone, alter with age progression and could serve as aging clock feat

SUBMITTER: Li Y 

PROVIDER: S-EPMC12669247 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature