The effect of recombinant botulinum neurotoxin A on neuropathic pain in the spared nerve injury mouse model.

ABSTRACT: Neuropathic pain following traumatic nerve injury is a disabling chronic pain disorder characterized by sensory abnormalities such as mechanical allodynia. Botulinum neurotoxin type A (BoNT/A) has shown analgesic properties in a range of clinical pain conditions and in animal models. Here, we investigated analgesic efficacy of recombinant BoNT/A1 (rBoNT/A1; IPN10260) in the spared nerve injury (SNI) mouse model of neuropathic pain. Potential tissue site and mechanisms of action were explored by analyzing a series of pain biomarkers in the ipsilateral dorsal root ganglion (DRG) and the spinal cord. C57Bl6 mice received either SNI- or a sham surgery 14 days before being treated with either rBoNT/A1 or vehicle. Mechanical sensitivity was evaluated in von Frey tests performed at baseline and t

SUBMITTER: E Hammer R 

PROVIDER: S-EPMC12669262 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature