Chronic Styrene Exposure Causes Oxidative Stress, Neuroinflammation, and Hippocampal Memory Dysfunction via NLRP3 Inflammasome Activation.

ABSTRACT: Several studies focused on the molecular mechanisms linking oxidative stress and inflammation, due to their crucial role in different pathological conditions, including neurodegenerative disorders. Here, we studied the link between redox unbalance and neuroinflammation in a model of styrene-induced toxicity in the hippocampus. We used a rat model of chronic styrene exposure to assess its impact on hippocampal function. Behavioral tests were performed to evaluate recognition and spatial memory. Molecular and histological analyses were carried out to measure ROS production, inflammatory markers (COX-2, TNF-α, IL-1β), and immunoreactivity for IBA-1 and GFAP. Synaptic alterations, activation of pro-apoptotic pathways, and NLRP3 inflammasome levels were also evaluated. We found that toxic expos

SUBMITTER: Montuoro R 

PROVIDER: S-EPMC12669270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature