Lipidomic fingerprints reveal sex-, age-, and disease-dependent differences in the TgF344-AD transgenic rats.

ABSTRACT:

Background

Gathering information on Alzheimer's disease (AD) progression in human poses significant challenges due to the lengthy timelines and ethical considerations involved. Animal AD models provide a valuable alternative for conducting mechanistic studies and testing potential therapeutic strategies. Disturbed lipid homeostasis is among the earliest neuropathological features of AD.

Aim

To identify longitudinal plasma lipidomic changes associated with age, sex, and AD in male and female TgF344-AD and wild-type rats.

Methods

A total of 751 lipids in 141 rats (n = 73 TgF344-AD; n = 68 WT) were quantified at 12, 25, 50, and 85 weeks). Differential abundances of lipids were assessed using generalized logical regression models, correcting for i) age and sex, for ii) in

SUBMITTER: Yin C 

PROVIDER: S-EPMC12669273 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature