Longitudinal Analysis of Estrogen Receptor Gene Methylation, Estradiol, and Depressive Symptoms During the Perinatal Period.

ABSTRACT: DNA methylation of estrogen receptor genes (ESR1, ESR2, and GPER) may affect the expression of the estrogen receptors (ERs) alpha, beta, and G protein-coupled estrogen receptor (GPER). Altered receptor expression may in turn affect the receptors' sensitivity to estrogen, thereby modulating vulnerability to depression during periods of estrogen fluctuation. The aim of this study was to investigate the association between the methylation of ESR1, ESR2, and GPER, depressive symptoms, and estradiol during the perinatal period using a longitudinal design. A total of 159 women were followed longitudinally from 34 to 36 weeks of gestation to 8-12 weeks postpartum. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Salivary estradiol levels were quantified, an

SUBMITTER: Zorzini G 

PROVIDER: S-EPMC12669334 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature