Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo.

ABSTRACT:

Introduction

Perfluorooctanoic acid (PFOA) is a widespread environmental contaminant that interferes with multiple biological pathways, with lipid metabolism being particularly vulnerable. Early-life exposure may disrupt hepatic function during development, but the underlying mechanisms are not fully understood.

Objectives

This study investigated how in ovo exposure to PFOA affects hepatic metabolism in the developing chicken embryo, with a focus on identifying altered metabolic pathways and potential mediators of toxicity.

Methods

Fertilized chicken eggs (Gallus gallus domesticus) were exposed in ovo to six concentrations of PFOA (0-5 µg/g egg). Embryonic liver tissues were analysed by comprehensive metabolomic profiling using two complementary ultra-high-performance

SUBMITTER: Scherbak N 

PROVIDER: S-EPMC12669338 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature