Deciphering Ferroptosis-Related Astrocyte Subpopulations and Diagnostic Biomarkers in Parkinson's Disease through RNA Transcriptomics.

ABSTRACT: Parkinson`s disease (PD) is the second most prevalent neurodegenerative disorder, and increasing evidence indicates that glial activation plays a significant role in ferroptosis and the subsequent neurodegeneration. In this study, we aimed to identify ferroptosis-related astrocytes exhibiting elevated inflammation scores in PD patients. The single-cell and bulk RNA transcriptomic profiles of PD samples were collected from the Gene Expression Omnibus database. We characterized seven cell types in the substantia nigra region of PD and normal samples, and discovering that astrocytes from the PD group interacted with microglia and oligodendrocytes. Furthermore, we identified five distinct astrocyte subpopulations: Astro-C0, -C1, -C2, -C3, and -C4. The Astro-C1 subpopulation was found to be cor

SUBMITTER: Gong Z 

PROVIDER: S-EPMC12669358 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature