Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study.

ABSTRACT:

Introduction

Odanacatib (ODN), a cathepsin K inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued. Here, we propose ODN as a topical treatment, the coating of dental implants, to achieve an anabolic shift of early osseointegration.

Material and methods

To this aim, we have coated double acid etching titanium implants (SLA) with and without ODN dispersed in a simulated body fluid (SBF). The implants were inserted into the tibia of 72 male Wistar rats and osseointegration was studied on Days 15 and 40. Biomechanical testing, micro-computed microtomography, and histomorphometric analyses were performed

SUBMITTER: Dos Santos Sanches N 

PROVIDER: S-EPMC12669435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature