The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank.

ABSTRACT: Neuropsychiatric symptoms are a significant yet often overlooked aspect of Parkinson's disease (PD). Using UK Biobank data, we examined associations between neuropsychiatric dimensions and PD risk markers. Factor analysis identified four dimensions-Depression, Anxiety, Adult Stress-Adversity, and Alcohol- and Substance-Related Behaviours (ASRB) -across three groups: PD, healthy controls, and cerebrovascular disease (CVD) as neurological controls. These dimensions showed distinct patterns in PD. Depression scores were significantly elevated, while ASRB scores were consistently lower. Neuroimaging linked ASRB to subcortical changes specific to PD, particularly quantitative susceptibility mapping in the substantia nigra, consistent with the dopaminergic system's role in goal-directed behaviou

SUBMITTER: Attaallah B 

PROVIDER: S-EPMC12669592 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature