Contemporary in vivo rodent electroconvulsive therapy (ECT) models in translational depression research: a systematic review.

ABSTRACT: Electroconvulsive therapy (ECT) has been established as an efficacious and safe treatment for severe and/or treatment-resistant depression. However, despite decades of research, the exact biological signature of the mechanism of action of ECT has yet to be elucidated. As a translational tool, electroconvulsive stimulation (ECS), the preclinical rodent equivalent of ECT, offers the unique opportunity for further knowledge under controlled laboratory conditions. Here, for the first time, a systematic review following the PRISMA 2020 statement is presented, covering mouse and rat studies investigating the biobehavioral effects of ECS in chronic stress-based depression models. For this purpose, the PubMed and Web of Science databases (period: 01.01.2000 to 05.10.2023) were screened for differe

SUBMITTER: Kokolakis E 

PROVIDER: S-EPMC12669789 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature