Comparison of Ideal vs. Actual Body Weight Dosing of Intravenous Immunoglobulins for Immune Thrombocytopenia: A Retrospective Analysis.

ABSTRACT:

Introduction

Intravenous immunoglobulin (IVIG) is a weight-based therapy used to treat immune thrombocytopenia (ITP). Although pharmacokinetic data support the use of ideal body weight (IBW)-based dosing, clinical outcomes for this dosing strategy are lacking.

Materials and methods

This retrospective, multicenter chart review was conducted across five institutions compared clinical outcomes and costs for patients with ITP treated with IVIG dosed via actual body weight (ABW) or IBW. Data were collected from November 1, 2019 to April 10, 2024. The primary outcome was early platelet response, and secondary outcomes included length of stay (LOS) and increase in platelet count.

Results

A total of 94 patients were included for analysis. No significant differences were noted

SUBMITTER: Lababidi H 

PROVIDER: S-EPMC12669801 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature