Urinary Gonadotropins as Markers of Puberty in Girls and Boys During Late Childhood and Adolescence: Evidence From the SCAMP Cohort.

ABSTRACT:

Introduction

Urinary gonadotropins measurement is a noninvasive method for evaluation of pubertal development and may have utility in population studies.

Objectives

To investigate the utility of urinary gonadotropins as a noninvasive biomarker of puberty in boys and girls.

Methods

School-based adolescent cohort study with two time points for collecting school time urine samples and self-reported assessment of puberty through the Pubertal Development Scale (PDS) approximately 2 years apart. FSH and LH were measured by two-site sandwich immunoassay and corrected for creatinine excretion.

Results

A total of 941 samples from 741 girls and 1198 samples from 899 boys aged between 11 and 16 years were analysed. Samples were collected at a median age of 12.3 years (ran

SUBMITTER: Spiers A 

PROVIDER: S-EPMC12669817 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature