KLF1 coordinates specialized transcriptional networks required to maintain the integrity of terminal erythropoiesis.

ABSTRACT: Krüppel-like factor 1 [KLF1; also known as erythroid Krüppel-like factor (EKLF)] is a C2H2 zinc finger transcription factor that plays a crucial role in all aspects of erythropoiesis. Mutations in KLF1 lead to diverse phenotypes ranging from mild to severe anemias. Individuals with a heterozygous E325K mutation [congenital dyserythropoietic anemia (CDA) type IV] exhibit impaired erythroid terminal differentiation and increased presence of binucleate erythroblasts. We have previously shown that KLF1 is necessary for cell cycle exit and enucleation in mouse primary cells. In the present study, we discovered that genes involved in cell motility, cell division and mitotic pathways are all directly regulated by KLF1. Klf1-/- cells exhibit increased numbers of binucleated erythroblasts and DNA b

SUBMITTER: Gnanapragasam MN 

PROVIDER: S-EPMC12669967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature