EIF3M as a pan-cancer biomarker: prognostic significance and immune infiltration association.

ABSTRACT:

Background

EIF3M, a core subunit of eukaryotic translation initiation factor 3, plays a pivotal role in protein synthesis by regulating the assembly of the 43S initiation complex. However, its biological functions in cancer remain poorly understood. To further investigate the clinical translational value and underlying mechanisms of EIF3M in tumors, this study conducted comprehensive bioinformatic analysis of EIF3M across various tumor types.

Methods

We utilized publicly available databases to perform a comprehensive bioinformatics analysis of EIF3M's biological roles in oncogenesis, aiming to elucidate its pan-cancer expression patterns and prognostic significance. Furthermore, we conducted an integrative multi-omics analysis incorporating methylation profiling, co-expresse

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12669982 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature