A systematic review and meta-analysis of circulating 25-hydroxyvitamin D concentration and vitamin D status worldwide.

ABSTRACT:

Background

Vitamin D deficiency is a public health concern; however, data on its global prevalence are limited. We reported pooled mean circulating 25-hydroxyvitamin D (25(OH)D) concentration and estimated the prevalence of concentration according to commonly reported thresholds for general, healthy populations worldwide.

Methods

We searched MEDLINE, Embase, Web of Science, Global Index Medicus and grey literature sites. We included cross-sectional and cohort studies published since 2011 that reported circulating 25(OH)D concentration in general, healthy populations of all ages. Using random-effects meta-analysis, we pooled data on circulating 25(OH)D concentration and prevalence estimates according to thresholds by continent, country, latitude, sex, adults/children, season,

SUBMITTER: Dunlop E 

PROVIDER: S-EPMC12670000 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature