Mechanical ventilation amplifies intratracheal lipopolysaccharide-induced plasma and brainstem inflammation in preterm foetal sheep.

ABSTRACT: Preterm newborns exposed to infection/inflammation in utero are at an increased risk of requiring respiratory support at birth, often in the form of mechanical ventilation. Mechanical ventilation and intrauterine inflammation independently cause inflammation in brainstem respiratory-related centres. However, the synergistic effect of intrauterine inflammation and mechanical ventilation on brainstem inflammation is unknown. We hypothesized that 24 h of mechanical ventilation after intratracheal LPS exposure exacerbates inflammation in the brainstem respiratory-related centres of preterm foetal sheep. Preterm foetal sheep (110 ± 1 days' gestation) were surgically instrumented with catheters and tubing for in utero ventilation (VENT). At 115 ± 3 days, foetal sheep were randomly

SUBMITTER: Vidinopoulos K 

PROVIDER: S-EPMC12670003 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature