TRPM7 and magnesium orchestrate human CD4 T-cell activation and differentiation.

ABSTRACT: T-lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7, transient receptor potential cation channel subfamily M, member 7, has previously been implicated in cellular Mg²⁺ homeostasis, proliferation, and immune cell modulation. Here, we show that pharmacological and genetic silencing of TRPM7 leads to diminished activation and influences signaling pathways that guide human T_H17 or T_reg cell differentiation, following TCR-mediated stimulation. In primary human CD4 T cells and CRISPR-Cas9-engineered Jurkat T cells, inactivation or loss of TRPM7 led to distorted Mg²⁺ homeostasis and Ca²⁺ signaling, reduced NFAT translocation, de

SUBMITTER: Madlmayr A 

PROVIDER: S-EPMC12670122 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature