Analysis of prognostic factors influencing brain metastasis in EGFR-mutant lung adenocarcinoma and comparison of prognostic assessment models.

ABSTRACT: Patients with EGFR-mutant lung adenocarcinoma are at risk for brain metastasis (BM), which worsens prognosis. The present study aimed to investigate the prognostic factors affecting the prognosis of patients with locally advanced lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations following the development of brain metastases (BM) after radical radiotherapy and chemotherapy. The present study also aimed to evaluate four scoring systems: Recursive partitioning analysis (RPA), diagnosis-specific graded prognostic assessment (DS-GPA), basic score for BM (BSBM) and lung cancer-associated molecular (Lung-mol) GPA, for their predictive roles. A retrospective analysis was performed on the clinical data of 260 patients with lung adenocarcinoma with BM and EGFR mutation admit

SUBMITTER: Miao J 

PROVIDER: S-EPMC12670208 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature