Fucosyltransferase 8-Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1-TNF Signaling Axis to Promote Lung Cancer Progression.

ABSTRACT:

Background

Lung cancer, representing a predominant form of pulmonary malignancy, demonstrates significant disease burden and poor clinical outcomes. Circular RNAs (circRNAs) have emerged as critical regulators in various cancers, including lung cancer. However, the specific roles and mechanisms of circRNAs in lung cancer remain largely unexplored.

Methods

Differential circRNA expression was analyzed using GEO datasets GSE101586 and GSE112214. CircFUT8 was prioritized for its upregulation in lung cancer tissues. In vitro and in vivo functional experiments evaluated its effects on cell proliferation, apoptosis, migration, and invasion. RNA pull-down, immunofluorescence, and western blotting assessed interactions with ENO1. Macrophage polarization was examined via cocultures an

SUBMITTER: Ren Y 

PROVIDER: S-EPMC12670297 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature