Metal and Additive-Free Nondirected Meta-C-S Bond Formation on Anilines: Toward Biologically Relevant <i>S</i>‑Aryl Dithiocarbamates.

ABSTRACT: The site-selective C-H functionalization to install meta-C-S bonds on aniline derivatives is highly desirable, due to the preponderance of resulting compounds in numerous medicinally relevant compounds. However, the execution of the same is far from being trivial, due to the intrinsic electronic bias of anilines and concerns associated with the ready availability of an appropriate and odorless sulfur source. Accordingly, we demonstrate a metal- and additive-free, one-pot, multicomponent reaction between p-anisidines/anilines, carbon disulfide, and aliphatic amines to install an otherwise difficult meta-C-S bond on anilines with exclusive regioselectivity, while furnishing an array of biologically relevant anisidine-derived S-aryl dithiocarbamates. The method exhibits broad sc

SUBMITTER: Parida SK 

PROVIDER: S-EPMC12670321 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature