Sinomenine ameliorates lipopolysaccharide-induced acute lung injury by stimulating M2 polarization and suppressing pyroptosis in alveolar macrophages.

ABSTRACT:

Objectives

Alveolar Macrophages (AMs), key defenders against Acute Lung Injury (ALI), are a potential therapeutic target. Sinomenine (SINO) has shown protective effects against ALI. This study investigates whether SINO exerts its protection by modulating AM polarization and pyroptosis.

Method

39 mice were divided into three groups: control, Lipopolysaccharide (LPS), and ALI+SINO groups. After administration of vehicle and SINO (60 mg/kg) for 1 h, mice were intratracheally injected with LPS at 10 mg/kg to induce ALI. A separate cohort received 20 mg/kg LPS for survival analysis. The survival rate, pathological alteration, lung Wet/Dry weight (W/D) ratio, and Myeloperoxidase (MPO) activity in the lung, as well as neutrophil count and protein content in Bronchoalveolar Lavage F

SUBMITTER: Jian X 

PROVIDER: S-EPMC12670450 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature