Fetal exposure to a mixture of endocrine-disrupting chemicals and biomarkers of male fecundity: A population-based cohort study.

ABSTRACT:

Background

Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures.

Objectives

We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood.

Materials and methods

The study population comprised 841 young adult males enrolled in the Fetal Programming of Semen Quality cohort, established as a male offspring sub-cohort within the Danish National Birth Cohort. Maternal blood samples were analyzed for concentrations of per- and polyfluoroalkyl substances (PFAS), phthalate metabolites, and triclosan. We used quantile g-computation to estimate the change in semen characteristics, testicular volume, and reproductive

SUBMITTER: Hull SD 

PROVIDER: S-EPMC12670469 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature