Mannose Targeting and Hydrophobic Tuning of Polycationic Vectors for Efficient Immunostimulatory CpG Delivery.

ABSTRACT: The efficacy of nucleic acid-based therapeutics is often hindered by nuclease degradation and poor cellular uptake. To address these challenges, the complexation with cationic polymers to form polyplexes has been increasingly investigated. In our previous work, we developed a platform technology composed of a mannosylated block for targeting dendritic cells (DCs) via endocytic mannose receptor (CD206), an agmatinyl block for nucleic acid condensation in diblock copolymers (M₁₅-b-A₁₂, M₂₉-b-A₂₅, and M₅₈-b-A₄₅), elongated with a poly-(butyl acrylate) block to promote endosomal escape in triblock copolymers (M₂₉-b-A₂₉-b-B₉ and M₅₈-b-A_52</

SUBMITTER: Bellato F 

PROVIDER: S-EPMC12670563 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature