Causal effects of gut microbiome on aortic dissection: A mendelian randomization study.

ABSTRACT:

Introduction

Aortic Dissection (AD) is a severe vascular disease with high mortality. While its progression is rapid, the development of AD is a chronic disease process. The gut microbiome may play a crucial role in this process. This study aims to explore the potential causal association between gut microbiome and AD using Mendelian Randomization (MR).

Methods

This study employed a two-sample MR approach using Genome-Wide Association Study (GWAS) data from the Finnish population to investigate the causal association between gut microbiota and AD. Single Nucleotide Polymorphisms (SNPs) associated with 473 gut microbiota taxa were selected as instrumental variables, and various MR methods were applied to evaluate the causal effects. Sensitivity analyses were conducted to asse

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12670564 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature