Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancy.

ABSTRACT: African American women are disproportionately troubled with cardiometabolic complications of pregnancy (CMC_Preg), including gestational diabetes, gestational hypertension, and preeclampsia. These adverse outcomes of pregnancy often lead to future diagnoses of diabetes mellitus, chronic hypertension, and/or atherosclerosis. Lipid dysregulation is hallmark of these disorders. To investigate whether this lipid dysregulation is prolonged after pregnancy, we performed untargeted lipidomics on serum collected 8-10 months postpartum from African American women who were diagnosed with CMC_Preg and from those with uncomplicated, term deliveries. We identified 11 lipids that were significantly increased in the CMC_Preg group and lipid enrichment pathway analysis reveal

SUBMITTER: Maner-Smith K 

PROVIDER: S-EPMC12670567 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature