Cerebral phosphorus metabolite as imaging biomarkers in Alzheimer's disease: a ³¹P magnetic resonance spectroscopy study.

ABSTRACT: This study employed phosphorus-31 magnetic resonance spectroscopic imaging (31P-MRSI) to characterize hippocampal and frontal metabolic alterations in Alzheimer's disease (AD) and to evaluate their associations with cognitive decline. We enrolled 30 patients with AD, 26 with amnestic mild cognitive impairment (aMCI), and 25 healthy controls (HC), all of whom underwent ³¹P-MRSI using a 3.0 T MRI scanner with a dual-tuned ¹H/³¹P head coil. Spectroscopic data were acquired from the hippocampus, prefrontal gray matter, and prefrontal white matter regions for subsequent analysis.The results of this study indicate that compared to the HC groups, patients with AD showed a significantly reduced phosphocreatine to inorganic phosphate ratio in the hippocampal region

SUBMITTER: Zhao S 

PROVIDER: S-EPMC12670598 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature