Comorbid insomnia and sleep apnea is associated with worse verbal episodic memory in older females.

ABSTRACT:

Study objectives

To investigate whether comorbid insomnia and sleep apnea (COMISA) is associated with poor verbal memory in older adults, and whether this relationship is moderated by sex.

Methods

A total of 110 older adults aged (65-83), all diagnosed with obstructive sleep apnea, completed overnight polysomnography and cognitive testing. COMISA was defined as obstructive sleep apnea plus an Insomnia Severity Index score ≥ 11. Verbal memory was assessed via the delayed recall component of the Alzheimer's Disease Cooperative Study Preclinical Alzheimer's Cognitive Composite. Moderation analysis examined the interaction between COMISA and sex on verbal memory performance, adjusting for age, body mass index, APOE4 status, and education. Post hoc sleep architecture diffe

SUBMITTER: Holloway BM 

PROVIDER: S-EPMC12670621 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature