Comparative study between nalbuphine and dexmedetomidine for conscious sedation in patients undergoing colonoscopy: randomized comparative trial.

ABSTRACT:

Background

Sedation is increasingly preferred for patients undergoing colonoscopy to improve tolerance and procedural success. This study aimed to compare the sedative and analgesic profiles, as well as hemodynamic responses, of dexmedetomidine and nalbuphine during elective colonoscopies.

Methods

A total of 66 patients scheduled for colonoscopy were randomly divided into two equal groups: one received an intravenous bolus of dexmedetomidine (1 µg/kg) followed by a continuous infusion (0.5 µg/kg/h), and the other received nalbuphine (0.2 mg/kg IV). The primary endpoint was the assessment of sedation depth, while secondary endpoints included pain perception, cardiovascular stability, recovery measures, satisfaction scores, and the occurrence of adverse effects.

Results

SUBMITTER: Abdelrady MM 

PROVIDER: S-EPMC12670722 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature