Pioglitazone modulates metabolic adaptation and peripheral nerve regeneration after injury.

ABSTRACT: Peripheral nerves have an intrinsic capacity for regeneration after traumatic injury, with Schwann cells (SCs) playing a central role in orchestrating this complex process. Critical components of successful regeneration include SC reprogramming into repair SCs, debris removal and metabolic adaptations. Up to now, there are no pharmacological treatments available in the clinics to improve nerve regeneration. In this study, we investigated peroxisome proliferator-activated receptor gamma (PPARɣ) as a therapeutic target in the context of nerve regeneration, since we previously found this transcription factor to be involved in SC reprograming and metabolic adaptations. Therefore, we used a mouse model of sciatic nerve crush injury and applied the PPARɣ agonist pioglitazone (PIO) in two differe

SUBMITTER: Seitz A 

PROVIDER: S-EPMC12670764 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature