The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis.

ABSTRACT:

Background

Allergic conjunctivitis (AC) is a prevalent ocular surface disorder, with chronic or severe manifestations of AC frequently resulting in substantial ocular surface damage. The neuropeptide substance P (SP) plays a critical role in inflammation and immune regulation; however, its involvement in AC remains unclear. The objective of this study was to establish a murine model of persistent AC through repeated allergen exposure to investigate how SP and its downstream STAT3/STAT5 pathway modulate Th17/Treg imbalance and exacerbate ocular surface damage.

Methods

A persistent AC mouse model was established through repeated ovalbumin (OVA) challenges. The ocular surface damage in the mice was evaluated using slit lamp examination, H&E staining, fluorescein staining, PAS s

SUBMITTER: Bao J 

PROVIDER: S-EPMC12670797 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature