The European BestAgeing Study on microRNA candidates reveals distinct signatures with diagnostic and prognostic potential in cardiovascular disease.

ABSTRACT:

Background

Circulating miRNAs have emerged as promising biomarker candidates due to their stability and their role in regulating key pathological pathways in cardiovascular disease (CVD). Yet, large-scale, multicentre studies examining their diagnostic and prognostic potential are scarce. This study evaluates the potential of miRNA expression profiles to inform disease classification and risk stratification across major CVD phenotypes, including acute coronary syndrome (ACS), chronic coronary artery disease (CAD), dilated cardiomyopathy (DCM), and ischemic cardiomyopathy (ICM), in a large, multicentre European cohort.

Methods

We assessed genome-wide miRNA expression profiles in a total of 1209 cardiovascular patients and 848 controls in a uniform, standardized fashion, which

SUBMITTER: Reich C 

PROVIDER: S-EPMC12670801 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature