Preserved fascicular architecture predicts neuroma pain: a morphometric study.

ABSTRACT: Painful neuromas remain a major clinical challenge after limb amputation and peripheral nerve trauma. While histological features such as inflammation, fibrosis, and axonal sprouting have been proposed as contributors to neuropathic pain, direct clinicopathological correlations remain inconsistent. The role of internal nerve architecture, particularly the proportion of preserved, organized fascicular tissue, has not been quantitatively assessed in relation to pain intensity. To address this gap, this study investigates whether the relative amount of organized versus unorganized nervous tissue within neuromas correlates with patient-reported pain, independent of classical histological parameters. Accordingly, we performed whole-slide histological segmentation of peripheral nerve samples inc

SUBMITTER: Pardo LA 

PROVIDER: S-EPMC12670820 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature