Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats.

ABSTRACT:

Background

In order to elucidate the neuromodulatory mechanisms underlying therapeutic subthalamic deep brain stimulation (DBS), we here reverse-translate a methodological pipeline that integrates neurostimulation effect parameterization and molecular imaging.

Methods

¹⁸F-fluorodeoxyglucose positron emission tomography was performed in a human-mimicking A53T alpha-synuclein Parkinson's disease rat model and in control rats under both stimulation ON and OFF conditions, with additional CT scans acquired for each rat. Patient-derived approaches-including electrode modeling, electric field estimation, and volume of tissue activated measurement-were applied to assess stimulation effects at the stimulation spot.

Results

We revealed consistent hypometabolism in th

SUBMITTER: Chen J 

PROVIDER: S-EPMC12670866 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature