Exploring 1,3,4-oxadiazolyl sulfide derivatives as antidiabetic candidates: synthesis, antioxidant activity, SAR-study, molecular docking, and DFT-insights.

ABSTRACT: 1,3,4-Oxadiazoles are a vital class of heterocyclic compounds known for their diverse biological activities. In this study, a series of eight novel 1,3,4-oxadiazolyl sulfide derivatives 4a-h were synthesized and characterized using IR, NMR, and elemental analysis. The antioxidant activity of these derivatives was evaluated via DPPH and ABTS assays, revealing promising radical scavenging capabilities Compound 4 h emerged as the most potent antioxidant with SC₅₀ values of 9.88 µM (ABTS) and 12.34 µM (DPPH), outperforming standard antioxidants surpassing standard antioxidants such as ascorbic acid (SC₅₀ = 23.92 µM) and gallic acid (SC₅₀ = 21.24 µM). The impact of electron-donating and electron-withdrawing substituents on activity was demonstrated through a comprehensive structure-a

SUBMITTER: Khalaf NA 

PROVIDER: S-EPMC12670869 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature