Validation of normal reference ranges in cardiac magnetic resonance imaging: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

Normal reference ranges in cardiovascular imaging studies are typically established as the mean value plus and minus twice the standard deviation (SD) of a healthy reference cohort ("2 SD-method"). Although widely used for cardiac magnetic resonance (CMR), this approach has not been previously validated. The purpose of this study was to use longitudinal cohort data to assess the clinical predictive validity of normal reference values for cardiac CMR.

Methods

Normal reference ranges for left- and right ventricular (LV and RV) CMR parameters were derived from baseline exam data of 1518 participants (age 45-84years) in the Multi-Ethnic Study of Atherosclerosis (MESA) study without known CV disease and without established CV risk factors. Cut-off values at 1 and 2 SDs

SUBMITTER: Kawel-Boehm N 

PROVIDER: S-EPMC12670894 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature