Weight Change is Associated With Metabolic Liver Health in a General Population Extending Beyond Weight Loss Targets of International Guidelines.

ABSTRACT:

Background and aims

Weight loss of ≥3%-10% is recommended in metabolic dysfunction-associated steatotic liver disease (MASLD) management, according to current guidelines. We investigated the associations between weight change and impaired metabolic liver health and focused on associations beyond these recommendations.

Methods

Adults from the National Health and Nutrition Examination Survey 2017-2020, with data on 1-year weight history, controlled attenuation parameter and/or liver stiffness measurement (LSM) were selected. Exclusion criteria were age ≥80 years, body mass index <18.5 kg/m², excessive alcohol and viral hepatitis. Impaired metabolic liver health included MASLD (controlled attenuation parameter ≥275 dB/m with ≥1 cardiometabolic riskfactor), at-risk me

SUBMITTER: van Kleef LA 

PROVIDER: S-EPMC12670896 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature