Splenic switch-off in three-dimensional adenosine stress cardiac magnetic resonance perfusion for differentiating true-negative from potentially false-negative studies identified by fractional flow reserve.

ABSTRACT:

Background

False-negative cardiovascular magnetic resonance (CMR) perfusion results may arise from inadequate stress responses, even when patients exhibit an adequate clinical or heart-rate response to adenosine. This study aimed to explore the ability of qualitative and quantitative splenic switch-off (SSO) markers to differentiate true-negative from potentially false-negative adenosine stress-perfusion CMR findings in a cohort where fractional flow reserve (FFR) was used to adjudicate lesion significance.

Methods

Patients with known or suspected coronary artery disease (CAD) from five centers underwent three-dimensional (3D) adenosine stress perfusion CMR and coronary angiography with FFR. SSO was assessed qualitatively using both standard stress-to-rest (SSO) and a stress

SUBMITTER: Karolyi M 

PROVIDER: S-EPMC12670903 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature