Impact and effectiveness of RSV maternal immunization on infant hospitalizations in Buenos Aires: a hospital-based, multicentre, retrospective surveillance cohort study.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a major cause of hospitalizations and mortality in young infants worldwide. The RSVpreF maternal immunization (MI) was recently introduced in Argentina.

Methods

This study assessed the impact of RSVpreF MI on RSV-related acute lower respiratory tract infections (ALRTI) hospitalizations through a hospital-based, multicentre, retrospective surveillance cohort study, and measured vaccine effectiveness (VE) using a nested test-negative case-control study. Data of hospitalized infants under 18 months of age was collected and analysed within seven years from three Argentine tertiary hospitals. VE analysis included ALRTI-hospitalized infants who were born between March 1 and November 9, 2024, were under 6 months of age when tested for

SUBMITTER: Razzini JL 

PROVIDER: S-EPMC12670925 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature