Implementation of a stepped anti-inflammatory reliever therapy intervention with budesonide-formoterol 160/4·5 mcg by Turbuhaler versus usual care for adults presenting during exacerbations of obstructive lung disease suggestive of asthma or chronic obstructive pulmonary disease in a resource-limited setting: an open-label, cluster randomised trial.

ABSTRACT:

Background

In resource-limited countries, chronic respiratory disease is common, and access to diagnosis and to the multiple medications in asthma and chronic obstructive pulmonary disease guidelines is limited. Building on a previous pilot study, we hypothesised that implementation of a simple stepped anti-inflammatory reliever (AIR) approach with budesonide-formoterol in patients presenting with obstructive airways disease and recurrent exacerbations in resource-limited settings would reduce exacerbations compared to usual care.

Methods

We conducted a 52-week open-label, cluster randomised controlled trial among adults presenting with recurrent acute respiratory symptoms in Vietnam. 40 district health facilities were assigned to usual care or intervention, which comprised

SUBMITTER: Fox GJ 

PROVIDER: S-EPMC12670951 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature