Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population.

ABSTRACT:

Background

Nicotine has been associated with cognitive functions such as memory and attention, with serum neurofilament light chain (sNfL) as a biomarker for neurological diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). However, the associations between nicotine and its metabolites and sNfL levels remain underexplored. This study aims to investigate the associations of serum and urine levels of cotinine and trans-3'-hydroxycotinine (hydroxycotinine) with sNfL levels in a broad population.

Methods

Employing data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014, this cross-sectional study applied multivariable linear regression models and restricted cubic splines to examine the links between cotinine, hydroxycotinine (both in s

SUBMITTER: Ji Q 

PROVIDER: S-EPMC12670970 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature